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OCR: molecule, This ACTH is derived from a large precursor pro-opiomelanocortin (POMC) (Fig. 9.7) lat contain precursor gives rise to three molecules ISH) the melanocyte-stimulating hormone (I containing sequence: the amino-terminal sequence Land the y-MSH sequence; ACTH with c-MSI ide B-lipotrophin (B-LPH) with B- MSH pep ese sequences. The relative importance of th rs in the molecules in the pigmentation that occ eloped for disease is unclear. Assays have been det nd for the amino-terminal sequence (N-POC) high in B-LPH. The levels of these molecules ar re stable in Addison's disease and, since they are m e useful in plasma than ACTH, they may prove to biochemical diagnosis, particularly whe ifuge) are sample-handling facilities (e.g. cold cent unavailable.